Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years
Identifieur interne : 001545 ( Main/Exploration ); précédent : 001544; suivant : 001546Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work‐up, and treatment for patients till the age of 18 years
Auteurs : Riccardo Haupt [Italie] ; Milen Minkov [Autriche] ; Itziar Astigarraga [Espagne] ; Eva Sch Fer [France] ; Vasanta Nanduri [Royaume-Uni] ; Rima Jubran [États-Unis] ; R. Maarten Egeler [Canada] ; Gritta Janka [Allemagne] ; Dragan Micic [Serbie] ; Carlos Rodriguez-Galindo [États-Unis] ; Stefaan Van Gool [Belgique] ; Johannes Visser [Royaume-Uni] ; Sheila Weitzman [Canada] ; Jean Donadieu [France]Source :
- Pediatric Blood & Cancer [ 1545-5009 ] ; 2013-02.
English descriptors
- Teeft :
- Active disease, Additional testing, Alanine transaminase, Anna hospital, Aspartate transaminase, Assistance publique hopitaux, Biopsy, Birbeck granules, Bone involvement, Bone lesions, Bone marrow, Bone scan, Bronchoalveolar lavage, Cambridge university press, Cancer research institute, Cell histiocytosis, Cell transplantation, Cerebellar function assessment, Cerebellar syndrome, Childhood cancer survivors, Childrens hospital, Clavicular line, Clinical classification, Clinical course, Clinical findings, Coagulation studies, Complete resolution, Consensus guidelines, Costal margin, Dental development, Diabetes insipidus, Disease activity, Disease form, Disease progression, Donadieu, Dysfunction, Egeler, Euro histio, General agreement, Gritta janka, Growth failure, Growth hormone, Guideline, Haupt, Hemophagocytic syndrome, High resolution, Histiocyte society, Histiocytic, Histiocytic disorders, Histiocytosis, Hopital trousseau, Hospital universitario cruces barakaldo, Imaging, Insipidus, Intravenous immunoglobulin, Involvement, Iron deficiency, Itziar astigarraga, Jean donadieu, Langerhans, Langerhans cell histiocytosis, Lesion, Liver enzymes, Liver involvement, Lung involvement, Lymph, Lymph node, Lymph nodes, Macrophage activation, Magnetic resonance imaging, Main endpoint, Milen minkov, Multisystem, Multisystem langerhans cell histiocytosis, Neurological, Node, Nodule, Oncol, Organ involvement, Orthopedic surgeon, Other causes, Other organs, Oxaloacetic transaminase, Pediatr, Pediatr blood cancer, Pediatr oncol, Pediatr orthop, Permanent consequences, Pilot study, Pubertal development, Puberty, Pulmonary involvement, Pyruvic transaminase, Radiation therapy, Rapid growth, Rare cases, Rare disease, Research society, Risk factors, Risk lesions, Risk organ, Risk organ involvement, Risk organs, Sclerosing cholangitis, Sequela, Sheila weitzman, Sick children, Single system, Skeletal radiograph, Skin rash, Skull base, Steroid, Such patients need, Syndrome, System langerhans cell histiocytosis, Systemic therapy, Temporal bone, Tissue extension, Tomography, Topical steroids, Transaminase, Treatment options, Vasanta nanduri, Vertebra plana, Vertebral involvement, Weekly bolus, Weitzman, Wiley periodicals, Young children.
Abstract
These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work‐up, and treatment and long‐term follow‐up of LCH patients are presented. Pediatr Blood Cancer 2013;60:175–184. © 2012 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.
Url:
DOI: 10.1002/pbc.24367
Affiliations:
- Allemagne, Autriche, Belgique, Canada, Espagne, France, Italie, Royaume-Uni, Serbie, États-Unis
- Californie, Hambourg, Massachusetts, Vienne (Autriche), Île-de-France
- Hambourg, Paris, Vienne (Autriche)
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Gaslini, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Minkov, Milen" sort="Minkov, Milen" uniqKey="Minkov M" first="Milen" last="Minkov">Milen Minkov</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Children's Cancer Research Institute, St. Anna Children's Hospital, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Astigarraga, Itziar" sort="Astigarraga, Itziar" uniqKey="Astigarraga I" first="Itziar" last="Astigarraga">Itziar Astigarraga</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Cruces Barakaldo, Barakaldo</wicri:regionArea><wicri:noRegion>Barakaldo</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fer, Eva" sort="Sch Fer, Eva" uniqKey="Sch Fer E" first="Eva" last="Sch Fer">Eva Sch Fer</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris</wicri:regionArea><wicri:noRegion>Assistance Publique – Hopitaux de Paris</wicri:noRegion><wicri:noRegion>Assistance Publique – Hopitaux de Paris</wicri:noRegion></affiliation></author><author><name sortKey="Nanduri, Vasanta" sort="Nanduri, Vasanta" uniqKey="Nanduri V" first="Vasanta" last="Nanduri">Vasanta Nanduri</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Watford General Hospital, Watford</wicri:regionArea><wicri:noRegion>Watford</wicri:noRegion></affiliation></author><author><name sortKey="Jubran, Rima" sort="Jubran, Rima" uniqKey="Jubran R" first="Rima" last="Jubran">Rima Jubran</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Children's Hospital of Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Egeler, R Maarten" sort="Egeler, R Maarten" uniqKey="Egeler R" first="R. Maarten" last="Egeler">R. Maarten Egeler</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Janka, Gritta" sort="Janka, Gritta" uniqKey="Janka G" first="Gritta" last="Janka">Gritta Janka</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Center Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Micic, Dragan" sort="Micic, Dragan" uniqKey="Micic D" first="Dragan" last="Micic">Dragan Micic</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Mother and Child Health Institute of Serbia “Dr Vukan Cupic,” Belgrade</wicri:regionArea><wicri:noRegion>” Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Alindo, Carlos" sort="Rodriguez Alindo, Carlos" uniqKey="Rodriguez Alindo C" first="Carlos" last="Rodriguez-Galindo">Carlos Rodriguez-Galindo</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana Farber Cancer Institute, Children's Hospital Boston, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Van Gool, Stefaan" sort="Van Gool, Stefaan" uniqKey="Van Gool S" first="Stefaan" last="Van Gool">Stefaan Van Gool</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gasthuisberg, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Visser, Johannes" sort="Visser, Johannes" uniqKey="Visser J" first="Johannes" last="Visser">Johannes Visser</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospitals of Leicester, Leicester Children's Hospital, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Weitzman, Sheila" sort="Weitzman, Sheila" uniqKey="Weitzman S" first="Sheila" last="Weitzman">Sheila Weitzman</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Donadieu, Jean" sort="Donadieu, Jean" uniqKey="Donadieu J" first="Jean" last="Donadieu">Jean Donadieu</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris</wicri:regionArea><wicri:noRegion>Assistance Publique – Hopitaux de Paris</wicri:noRegion><wicri:noRegion>Assistance Publique – Hopitaux de Paris</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Correspondence address: Service d'Hémato Oncologie Pédiatrique, Hopital Trousseau, 26 avenue du Dr Netter, F 75012 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatric Blood & Cancer</title><title level="j" type="alt">PEDIATRIC BLOOD AND CANCER</title><idno type="ISSN">1545-5009</idno><idno type="eISSN">1545-5017</idno><imprint><biblScope unit="vol">60</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="175">175</biblScope><biblScope unit="page" to="184">184</biblScope><biblScope unit="page-count">10</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-02">2013-02</date></imprint><idno type="ISSN">1545-5009</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1545-5009</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active disease</term><term>Additional testing</term><term>Alanine transaminase</term><term>Anna hospital</term><term>Aspartate transaminase</term><term>Assistance publique hopitaux</term><term>Biopsy</term><term>Birbeck granules</term><term>Bone involvement</term><term>Bone lesions</term><term>Bone marrow</term><term>Bone scan</term><term>Bronchoalveolar lavage</term><term>Cambridge university press</term><term>Cancer research institute</term><term>Cell histiocytosis</term><term>Cell transplantation</term><term>Cerebellar function assessment</term><term>Cerebellar syndrome</term><term>Childhood cancer survivors</term><term>Childrens hospital</term><term>Clavicular line</term><term>Clinical classification</term><term>Clinical course</term><term>Clinical findings</term><term>Coagulation studies</term><term>Complete resolution</term><term>Consensus guidelines</term><term>Costal margin</term><term>Dental development</term><term>Diabetes insipidus</term><term>Disease activity</term><term>Disease form</term><term>Disease progression</term><term>Donadieu</term><term>Dysfunction</term><term>Egeler</term><term>Euro histio</term><term>General agreement</term><term>Gritta janka</term><term>Growth failure</term><term>Growth hormone</term><term>Guideline</term><term>Haupt</term><term>Hemophagocytic syndrome</term><term>High resolution</term><term>Histiocyte society</term><term>Histiocytic</term><term>Histiocytic disorders</term><term>Histiocytosis</term><term>Hopital trousseau</term><term>Hospital universitario cruces barakaldo</term><term>Imaging</term><term>Insipidus</term><term>Intravenous immunoglobulin</term><term>Involvement</term><term>Iron deficiency</term><term>Itziar astigarraga</term><term>Jean donadieu</term><term>Langerhans</term><term>Langerhans cell histiocytosis</term><term>Lesion</term><term>Liver enzymes</term><term>Liver involvement</term><term>Lung involvement</term><term>Lymph</term><term>Lymph node</term><term>Lymph nodes</term><term>Macrophage activation</term><term>Magnetic resonance imaging</term><term>Main endpoint</term><term>Milen minkov</term><term>Multisystem</term><term>Multisystem langerhans cell histiocytosis</term><term>Neurological</term><term>Node</term><term>Nodule</term><term>Oncol</term><term>Organ involvement</term><term>Orthopedic surgeon</term><term>Other causes</term><term>Other organs</term><term>Oxaloacetic transaminase</term><term>Pediatr</term><term>Pediatr blood cancer</term><term>Pediatr oncol</term><term>Pediatr orthop</term><term>Permanent consequences</term><term>Pilot study</term><term>Pubertal development</term><term>Puberty</term><term>Pulmonary involvement</term><term>Pyruvic transaminase</term><term>Radiation therapy</term><term>Rapid growth</term><term>Rare cases</term><term>Rare disease</term><term>Research society</term><term>Risk factors</term><term>Risk lesions</term><term>Risk organ</term><term>Risk organ involvement</term><term>Risk organs</term><term>Sclerosing cholangitis</term><term>Sequela</term><term>Sheila weitzman</term><term>Sick children</term><term>Single system</term><term>Skeletal radiograph</term><term>Skin rash</term><term>Skull base</term><term>Steroid</term><term>Such patients need</term><term>Syndrome</term><term>System langerhans cell histiocytosis</term><term>Systemic therapy</term><term>Temporal bone</term><term>Tissue extension</term><term>Tomography</term><term>Topical steroids</term><term>Transaminase</term><term>Treatment options</term><term>Vasanta nanduri</term><term>Vertebra plana</term><term>Vertebral involvement</term><term>Weekly bolus</term><term>Weitzman</term><term>Wiley periodicals</term><term>Young children</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work‐up, and treatment and long‐term follow‐up of LCH patients are presented. Pediatr Blood Cancer 2013;60:175–184. © 2012 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>Serbie</li><li>États-Unis</li></country><region><li>Californie</li><li>Hambourg</li><li>Massachusetts</li><li>Vienne (Autriche)</li><li>Île-de-France</li></region><settlement><li>Hambourg</li><li>Paris</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Haupt, Riccardo" sort="Haupt, Riccardo" uniqKey="Haupt R" first="Riccardo" last="Haupt">Riccardo Haupt</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Minkov, Milen" sort="Minkov, Milen" uniqKey="Minkov M" first="Milen" last="Minkov">Milen Minkov</name></region></country><country name="Espagne"><noRegion><name sortKey="Astigarraga, Itziar" sort="Astigarraga, Itziar" uniqKey="Astigarraga I" first="Itziar" last="Astigarraga">Itziar Astigarraga</name></noRegion></country><country name="France"><noRegion><name sortKey="Sch Fer, Eva" sort="Sch Fer, Eva" uniqKey="Sch Fer E" first="Eva" last="Sch Fer">Eva Sch Fer</name></noRegion><name sortKey="Donadieu, Jean" sort="Donadieu, Jean" uniqKey="Donadieu J" first="Jean" last="Donadieu">Jean Donadieu</name><name sortKey="Donadieu, Jean" sort="Donadieu, Jean" uniqKey="Donadieu J" first="Jean" last="Donadieu">Jean Donadieu</name><name sortKey="Donadieu, Jean" sort="Donadieu, Jean" uniqKey="Donadieu J" first="Jean" last="Donadieu">Jean Donadieu</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Nanduri, Vasanta" sort="Nanduri, Vasanta" uniqKey="Nanduri V" first="Vasanta" last="Nanduri">Vasanta Nanduri</name></noRegion><name sortKey="Visser, Johannes" sort="Visser, Johannes" uniqKey="Visser J" first="Johannes" last="Visser">Johannes Visser</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Jubran, Rima" sort="Jubran, Rima" uniqKey="Jubran R" first="Rima" last="Jubran">Rima Jubran</name></region><name sortKey="Rodriguez Alindo, Carlos" sort="Rodriguez Alindo, Carlos" uniqKey="Rodriguez Alindo C" first="Carlos" last="Rodriguez-Galindo">Carlos Rodriguez-Galindo</name></country><country name="Canada"><noRegion><name sortKey="Egeler, R Maarten" sort="Egeler, R Maarten" uniqKey="Egeler R" first="R. Maarten" last="Egeler">R. Maarten Egeler</name></noRegion><name sortKey="Weitzman, Sheila" sort="Weitzman, Sheila" uniqKey="Weitzman S" first="Sheila" last="Weitzman">Sheila Weitzman</name></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Janka, Gritta" sort="Janka, Gritta" uniqKey="Janka G" first="Gritta" last="Janka">Gritta Janka</name></region></country><country name="Serbie"><noRegion><name sortKey="Micic, Dragan" sort="Micic, Dragan" uniqKey="Micic D" first="Dragan" last="Micic">Dragan Micic</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Van Gool, Stefaan" sort="Van Gool, Stefaan" uniqKey="Van Gool S" first="Stefaan" last="Van Gool">Stefaan Van Gool</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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